Normal Incidence of Diabetes in NOD Mice Tolerant to Glutamic Acid Decarboxylase
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چکیده
منابع مشابه
Normal Incidence of Diabetes in NOD Mice Tolerant to Glutamic Acid Decarboxylase
Experiments in nonobese diabetic (NOD) mice that lacked expression of glutamic acid decarboxylase (GAD) in beta cells have suggested that GAD represents an autoantigen essential for initiating and maintaining the diabetogenic immune response. Several attempts of inducing GAD-specific recessive tolerance to support this hypothesis have failed. Here we report on successful tolerance induction by ...
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Growing insight into the pathogenesis of type 1 diabetes (T1D) and numerous studies in preclinical models highlight the potential of antigen-specific approaches to restore tolerance efficiently and safely. Oral administration of protein antigens is a preferred method for tolerance induction, but degradation during gastrointestinal passage can impede such protein-based therapies, reducing their ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2003
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20030215